High-dose intravenous vitamin C treatment for COVID-19. COVID-19 pneumonia seems to be a lung injury caused by the hyperactivation immune effector cells. High-dose vitamin C may result in immunosuppression at the level of these effectors. Therefore, intravenous high-dose vitamin C could be safe and beneficial choice of treatment in the early stages of COVID-19. Introduction The two-time Nobel Prize-winning chemist Linus Pauling regarded vitamin C almost as a panacea; therefore, he claimed that high doses vitamin C could combat a host of illnesses, including cancer. He further believed that vitamin C would make the flu disappear completely off the face of the earth.Coronaviruses (CoVs) are large, enveloped, and positive sense RNA viruses that infect a broad range ofvertebrates and cause disease of medical and veterinary significance.Human respiratory corona viruses have been known since the 1960s to circulate worldwide and to cause respiratory infection with rather mild symptoms, suggesting that they are well-adapted to the human host. However, zoonotic coronaviruses, such as severe acute respiratory syndrome (SARS)and Middle East respiratory syndrome coronavirus (MERS-CoV), can cause severe respiratory tract infection with high mortality.
One of the many therapeutic approaches that have emerged, on the occasion of the appearance of a novel Coronavirus, is the use of vitamin C -ascorbic acid- due to its antioxidant properties at the cellular level.
Vitamin C has unknown properties, but it has been proven that it plays an important role in the development of the immune system.
The evidence that supports the proposal of the use of vitamin C in the treatment of COVID-19 is a pro-oxidant effect in the inflammatory mediators that produce the respiratory symptoms and anti-oxidant in the cells of the pulmonary epithelium, main objective of the new Coronavirus.